Vitamin B6 · Vitamin B9 · Vitamin B12
Three B vitamins supplied in their active, methylated forms, the versions the brain can use immediately, without requiring conversion by the body.
Control
Regeneration
Energy
protection
This B-vitamin trio targets homocysteine, the amino acid linked to accelerated brain ageing, while supporting every major pathway of brain chemical synthesis and neural health.
Homocysteine and brain health: Elevated homocysteine is one of the most well-established and modifiable risk factors for cognitive decline and brain atrophy. B6, B9 and B12 work together as a synergistic trio to metabolise homocysteine back into beneficial compounds, with each vitamin playing an essential and non-interchangeable role in the pathway.
Why forms matter enormously here: Because this trio works through a biochemical conversion pathway, using inactive forms introduces a conversion bottleneck at every step. Using P5P, 5-MTHF and Methylcobalamin removes those bottlenecks entirely, ensuring the pathway runs efficiently regardless of an individual's genetic profile.
How it fits the formula: Within Mentex Support, the B-vitamin trio provides the methylation and vascular health layer of the formula. It works synergistically with Citicoline and Phosphatidylserine to support the phospholipid synthesis and one-carbon metabolism pathways critical for long-term brain cell health.
- Neurotransmitter synthesis: B6 (P5P) is a required cofactor for the synthesis of serotonin, dopamine and GABA, the brain's primary mood, motivation and calming neurotransmitters.
- Myelin sheath maintenance: Methylcobalamin is essential for the synthesis and repair of myelin, the protective fatty sheath surrounding nerve fibres that maintains signal transmission speed and accuracy.
- SAMe production: 5-MTHF and Methylcobalamin both feed the methylation cycle that produces S-adenosylmethionine (SAMe), a mood-supporting compound involved in over 200 biochemical reactions in the brain.
- Brain energy metabolism: All three B vitamins act as coenzymes in mitochondrial energy production, supporting the ATP synthesis that powers neural activity and sustains mental performance throughout the day.
- MTHFR compatibility: Up to 40% of people carry MTHFR gene variants that impair folic acid and cyanocobalamin conversion. Using 5-MTHF and Methylcobalamin means Mentex Support works effectively for everyone, not just those without genetic variants.
Active methylated B-vitamin forms bypass conversion requirements for full bioavailability regardless of individual genetic profile.
In the Oxford VITACOG trial, a double-blind, placebo-controlled study in 168 older adults with mild cognitive impairment, two years of B6, B9 and B12 together lowered homocysteine and slowed the rate of brain shrinkage to 0.76% per year versus 1.08% on placebo (p=0.001), a roughly 30% reduction. The effect was strongest in those who started with the highest homocysteine. Read the full paper here:
View B-Vitamin Brain Atrophy Trial (Open Access)
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